Multidrug Resistance 1
Body function: Immune & Autoimmune
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Multidrug Resistance 1, or MDR1, is an inherited disorder affecting herding breeds like Collies and Australian Shepherds. A mutation in the ABCB1 gene causes abnormal production of p-glycoprotein, a compound that protects the brain from drugs and chemicals in a dog’s bloodstream. Dogs with this mutation are more sensitive to the negative side effects of medications like antiparasitics, antidiarrheals, and anticancer drugs.
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