Mucopolysaccharidosis VI
Body function: Metabolic & Digestive
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Mucopolysaccharidosis VI (MPS VI) is a progressive metabolic condition caused by an enzyme arylsulfatase B (ARBS) deficiency. This enzyme is essential for breaking down glycosaminoglycans (GAGs), large sugar molecules, within the cells. When ARSB is deficient, GAGs accumulate in the lysosomes, leading to cellular dysfunction and cell death. MPS VI is commonly seen in breeds such as Miniature Pinschers, Miniature Schnauzers, Welsh Corgis, and Chesapeake Bay Retrievers.
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