Globoid Cell Leukodystrophy
Body function: Immune & Autoimmune
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Globoid Cell Leukodystrophy, or Krabbe’s disease, is a fatal genetic disorder that occurs in terriers due to a mutation in the GALC gene. A deficiency of galactocerebrosidase affects the production of myelin, a substance that protects neurons. As a result, neurons fire incorrectly and deteriorate. Ultimately, this disease leads to death before 1 year of age.
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