Glanzmann Thrombasthenia Type I

Glanzmann Thrombasthenia Type 1 (GT) is an inherited bleeding disorder first identified in Pyrenean Mountain Dogs (Great Pyrenees). It's caused by a mutation in the ITGA2B gene, which leads to a deficiency or dysfunction of the platelet membrane glycoprotein αIIb β3 (also known as the fibrinogen receptor). This autosomal recessive condition results in impaired platelet aggregation and clot formation, leading to excessive bleeding tendencies. The disorder affects the dog's ability to form stable blood clots, making them prone to prolonged bleeding episodes.