Gallbladder Mucoceles
Body function: Metabolic & Digestive
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Gallbladder mucoceles (GBM) are characterized by an abnormal buildup of thick mucus-laden bile in the gallbladder due to a genetic mutation in the ABCB4 gene, which encodes the MDR3 phospholipase flippase transporter responsible for helping maintain the normal composition and flow of bile. This can lead to the expansion of the gallbladder, bile duct obstruction, and, in severe cases, gallbladder rupture and bile leakage into the abdomen. Middle-aged to older dogs are commonly affected, with breeds like Shetland Sheepdogs, Miniature Schnauzers, and Cocker Spaniels showing a higher genetic predisposition.
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