Factor VIII Deficiency (Old English Sheepdog)
Body function: Heart & Blood
In collaboration with
Hemophilia A in Old English Sheepdogs is a bleeding disorder caused by a mutation in the F8 gene on the X chromosome. This X-linked recessive condition primarily affects male dogs, while females can be carriers. The disorder results in a severe deficiency of coagulation Factor VIII, leading to impaired blood clotting.
In collaboration with