Factor VIII Deficiency (German Shepherd)
Body function: Heart & Blood
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Hemophilia A in German Shepherds is an inherited bleeding disorder caused by mutations in the F8 gene, which can lead to a deficiency in coagulation factor VIII. Two independent mutations have been identified: c.98G>A (HEMA-1) and c.16434>A (HEMA-2). This X-linked recessive condition primarily affects male dogs, while females are more commonly carriers.
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