Dominant Progressive Retinal Atrophy
Body function: Eyes
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Dominant Progressive Retinal Atrophy (dPRA) is a genetic eye disorder affecting English Mastiffs and Bullmastiffs. This condition is caused by a mutation in the RHO gene (Exon 1). It leads to the gradual deterioration of rod and cone cells in the retina, eventually resulting in complete blindness. dPRA is an autosomal dominant trait, meaning only one copy of the mutation is needed for the disorder to manifest.
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