Canine Leukocyte Adhesion Deficiency
Body function: Immune & Autoimmune
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Canine leukocyte adhesion deficiency (CLAD) is a blood disorder resulting from a mutation in the ITGB2 gene. It affects both blood cell and platelet activity, leading to abnormal blood clotting and poor immune system functioning. This mutation specifically affects Irish Setters and German Shepherd Dogs. Both parents must be carriers of the CLAD mutation for a puppy to be affected.
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