Alport Syndrome (English Cocker Spaniel)

Alport syndrome is a hereditary condition caused by a mutation in the COL4A4 gene that responsible for the structural integrity of type IV collagen in the kidneys. It leads to progressive renal failure and is identified in breeds such as Samoyeds, English Cocker Spaniels, Bull Terriers, and Dalmatians. There are three types of Alport syndrome: X-linked (XLAS), autosomal recessive (ARAS), and autosomal dominant (ADAS), with each type impacting specific breeds.